Hello, Gabrielle, and welcome to the Grammar Exchange.
So, the sentence "it makes me irritating" could be understood as "it makes me act in a irritating way, which can irritate someone else".
@Gustavo, Contributor posted:
Yes, it means it makes you an irritating person, that is, a person that can irritate others.
I agree with Gustavo's explanation, and that "It makes me irritating" must be understood to mean that it makes you an irritating person. I want to add, though, that I find "It makes me an irritating person" much more natural.
There is something very unusual about the sentence "It makes me irritating." I think such a sentence works much better with an insentient object: "That's what makes it (so) irritating."
With a person as object, it is far more natural to use a verb phrase after "make" when the person is the source of irritation: "It makes me irritate others." Adding a prepositional phrase would, however, improve the "irritating" version:
- It makes me irritating to others.
The basic meaning, of course, is "It makes others find me irritating" or "It makes me a source of irritation to others."