When someone's trying to tell you something is it rude to say 'what is it?' Or does it depend on the tone? I don't think you can say that to your boss, although friends and colleagues should be alright depending on the tone of course. Please correct me if I'm mistaken. 

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Ashraful, could you give us some more context, that is, an imaginary conversation in which you say: What is it?

Scenario 1:

A: Hey do you remember my weird Jewish neighbor? 

B: Yea what is it this time?

Scenario 2:

A: Hey man why are you so quiet? Is everything alright.

B: Yeah, I'm okay. 

A: I can see you're lying. What is it?

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